rbs6nations.com > Wales
Winger Cuthbert's only previous outing at Twickenham was Wales' 19-12 victory in 2012 when Scott Williams' 75th-minute try settled matters and inflicted a first defeat for Stuart Lancaster as England head coach.
Indeed, it was the only match England lost in the 2012 Championship and lightning struck twice 12 months later - Wales romping to a 30-3 victory in Cardiff, denying the Red Rose the Grand Slam, and the RBS 6 Nations crown for good measure.
As a result, Cuthbert is expecting an England side bent on revenge but after Wales got their hopes of a third straight title back on track with victory over France, he's relishing the challenge.
"I've only played England at Twickenham once, we went there and scored in the last minute," he said.
"They will be gunning for us from last year, we know what to expect and it will be a big fight.
"We've had ups and downs but we've found our form and hopefully we can hit full flow against England. It will be one of the biggest games of the tournament so far."