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That has merely stoked the flames for what is always a fiery and tight encounter in which England have failed to score a try in their last three trips north of the border.
To that end Lancaster has named a new midfield with Saracens trio Charlie Hodgson, Brad Barritt and Owen Farrell getting call-ups. Yet despite the interim head coach's talk of creating 'longevity' with an inexperienced squad, featuring eight uncapped players, he will only be judged by the final scoreline at Murrayfield.
"Maybe that naivety is a good thing," said Lancaster, who took over from Martin Johnson on an interim basis after the World Cup.
"Stepping out at Murrayfield will be the acid test. We can talk and talk, but until we go out there, that is when we will find out.
"At the outset I talked about two things - building a team that has longevity, and giving opportunities to new players," he said.
"We also talked about developing a style of play that allows us to express ourselves in terms of talent from both an attacking and a defensive point of view, and I like to think we have been true to our word in this selection.
"It's about a team for now and a team for the future, we're trying to achieve both.
"Equally, we also know that the result is paramount at the weekend, so we need to keep an eye on that."
Along with Barritt and Farrell, Northampton's Phil Dowson will make his debut as he starts in the back-row alongside new captain Chris Robshaw.
There are further new faces on the bench with Rob Webber, Geoff Parling, Ben Morgan, Lee Dickson and Jordan Turner-Hall set to make their debuts if they come on.
In contrast, Andy Robinson largely sticks with the tried and trusted with winger Lee Jones making his debut and No.8 David Denton making his first start.
Perhaps the biggest talking point was the selection of veteran Dan Parks at fly-half ahead of inexperienced pair Ruaridh Jackson and Greig Laidlaw.
Although the choice of Parks and his kicking game might be a conservative option, Robinson denied Scotland will be approaching the Calcutta Cup with a one-dimensional game plan.
"You think of the way we played against Wales two years ago when everyone said we were going to kick the ball, or when Glasgow played against Toulouse, ran Toulouse off the field and won the game out there," said Robinson. "Dan was the fly-half on both occasions.
"We've got to balance our game in the way that we play. That's the key for us; to be able to play in different ways, from the carrying of the forwards to that of Sean Lamont and Nick De Luca, to the quick feet of Max [Evans] and Lee Jones. We have to have a balance and Dan will lead that."

| Date | Home | Score | Away | Att |
|---|---|---|---|---|
| 2/2/13 | England | 38 - 18 | Scotland | |
| 4/2/12 | Scotland | 6 - 13 | England | |
| 13/3/11 | England | 22 - 16 | Scotland |
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