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Last year, Italy won the sides' encounter 16-12 at the Stadio Flaminio only for Scotland's unlikely last-day victory over Ireland to push the Azzurri to the bottom of the table.
But while Nick Mallett's side have established themselves as a force to be reckoned with on home soil, their last, and indeed only, win on the road in the Six Nations came at Murrayfield four years ago.
And full-back Masi, who played on the wing in that remarkable four-try 37-17 victory, says they could not afford any drop in the standards they set against Les Bleus.
"I am proud of what we did on Saturday at the Stadio Flaminio. It was a fantastic win for us and much deserved," he said.
"But that win is now in the past and we must look ahead to the game at Scotland.
"We have a duty not to settle for just one win.
"Scotland are a solid and dangerous team. They attack using all the pitch and they will try to impose the game by playing physical.
"We will have to show the same determination and aggressiveness that we displayed against France, and dominate from a physical standpoint if we are to win."
The victory over France has not stopped Mallett from continuing to chop and change his team selection with six alterations - a total of 21 changes over the course of the Championship.
For the fifth game running, the fly-half mantle switches between Luciano Orquera and Kris Burton while Alberto Sgarbi comes in for Gonzalo Garcia at inside centre.
In the pack Quintin Geldenhuys, Leonardo Ghiraldini and Salvatore Perugini all return while Paul Derbyshire starts his first match of the Championship.
In contrast, Scotland boss Andy Robinson, who has seen his side fail to score a single try in their last eight matches at Murrayfield, makes just one change: tighthead prop Geoff Cross replaces Moray Low after the Scottish scrum struggled in their 22-16 defeat against England.
But while there were plenty of positives to come out of their defeat at Twickenham - notably the destructive work of their back row and an assured display from fly-half Ruaridh Jackson - a loss to Italy would undo much of the good work Robinson had put in place during 2010.
And flanker John Barclay, whose sin-binning against England was thought by many to be the game's turning point, is under no illusions about what's riding on the game.
"It's a game we have to win - it's as simple as that," he said. "Unfortunately for the situation as it is right now, a lot of it is about restoring some pride, looking forward towards what's coming later in the year for us.
"We're hugely disappointed about what's gone before in the Championship, but that's gone now and the only thing we can do now is push forward and put in a huge performance this weekend."

| Date | Home | Score | Away | Att |
|---|---|---|---|---|
| 9/2/13 | Scotland | 34 - 10 | Italy | |
| 17/3/12 | Italy | 13 - 6 | Scotland | |
| 19/3/11 | Scotland | 21 - 8 | Italy |
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