But Brunel has also refreshed his half-back combination with Kristopher Burton and Edoardo Gori replacing Luciano Orquera and Tobias Botes in the hope of getting back to winning ways.

The 34-10 defeat to Scotland ended the Azzurri’s bid for successive wins after an opening weekend victory against France, and Brunel has urged his side to be positive.

He’s also called for a united performance to help quash the notion that Parisse will be missed.

“We have to look at this game against Wales with ambition. I think we can win it despite the absence of Parisse,” said Brunel.

“There are lots of players who are very influential in the game, Sergio is undoubtedly one of them, but he isn't the only one. We can't think this team is dependent on one player.”