It's all change for Warren Gatland this Saturday as Wales' head coach heads into the fifth and final round of fixtures in the 2014 RBS 6 Nations against Scotland in unfamiliar territory with no title to play for.
Throughout RBS 6 Nations history no two players have defined Italy more than Sergio Parisse and Martin Castrogiovanni - so it's fitting that they break the Azzurri's all-time caps record together on Saturday.
They are the captains of the last two British & Irish Lions tours yet neither started their country's opening victories of the 2014 RBS 6 Nations - but Paul O'Connell and Sam Warburton are ready to lead their sides into battle in Dublin on Saturday.
Philippe Saint-Andre insists his long-term objective for France remains the 2015 World Cup - but in the short-term he knows only too well the value of an RBS 6 Nations victory over Scotland on Saturday.
Italy reiterated the fact that they are closing the gap on the world's elite by their valiant defeat to England, but head coach Jacques Brunel will be desperate for a second win of the RBS 6 Nations against Ireland.
By their own admission they've got there the hard way but Wales have now trained their sights on defending their RBS 6 Nations title - and interim head coach Rob Howley has promised England the warmest of welcomes at the Millennium Stadium.
Wales may come into their RBS 6 Nations clash against Italy bearing the same record, but their momentum is certainly superior with interim head coach Rob Howley backing his starting XV to deliver once again.
England coach Stuart Lancaster is hoping to ignite the spirit of Twickenham after making just two changes from the side that so memorably beat New Zealand for the opening RBS 6 Nations clash against Scotland.