Ian McGeechan's side are traditionally slow starters - last season they left their revival later than ever - and today they were off the pace and shapeless in attack.
Irish were left reeling after finishing seventh last term, a position which meant they missed out on qualification for the Heineken Cup, but their rout at Twickenham was an impressive declaration of intent.
They were a far more threatening side, showing a creative spark in attack matched by a tigerish work ethic in the loose which left Wasps living off scraps.
Australian full-back Peter Hewat finished the afternoon with 16 points, successfully completing every kick at goal, and his haul ultimately proved the deciding factor.
Final-quarter tries from Tom Rees and Eoin Reddan gave the score respectability but Hewat's boot meant the outcome was never in doubt.