Ospreys coach Lyn Jones is confident they can bounce back in the Cup final clash with Leicester after their defeat at Saracens in the European Cup.
Jones has been in charge since the big-spending region was formed in 2003 and he insists they are on the right track.
"We have to keep on fighting and keep on improving. We have produced a lot more Welsh internationals than any other region in Wales since we started, which is a reflection of the hard work we are doing here," said Jones.
"To see 13 start against England, I was pleased as punch. They represented Wales with honour and to a high standard. We have been delighted with their achievements through the RBS 6 Nations.
"If we keep knocking on the door, it will open.
"We have won two League titles, are in our second cup final in a row when we play Leicester on Saturday and qualified for the quarter-finals of the European Cup for the first time.
"We will keep on progressing and, next year, we will turn up expecting to win."
Ospreys centre Gavin Henson is out of the game after suffering an ankle injury, while Wales scrum-half Mike Phillips (knee) and Scotland winger Nikki Walker (ankle) are also missing.
Organisers at Twickenham are predicting a crowd in excess of 60,000.
Rhino Rugby, who are the Official Licensee of the RBS 6 Nations for Supporter Apparel for the 2016 and 2017 competitions, have followed the example of Wasps Finance Plc in issuing a retail bond to fund their expansion plans.