Juan Martin Hernandez is set to line up against Ireland on November 22 after being included in the Argentina squad for next month's tour of Europe.
The full-back has recovered from a hand injury which forced him to miss the Pumas' 63-9 defeat to South Africa in August but returns to coach Santiago Phelan's 29-man squad.
Phelan has also included four uncapped players - CASI scrum-half Agustin Figuerola, Jockey Club Salta prop Juan Figallo, Universitario La Plata second-rower Mariano Galarza and Italy's Rovigo prop Juan Pablo Orlandi.
Phelan said: "After the defeat to South Africa, the idea is to have a fresh start.
"We must consider our position in the rankings ahead of the (2011) World Cup.
"This is a good chance to give the opportunity to young players we believe have the potential to progress.
"Juan Figallo was great in the Under-20 World Cup. He is a complete player. The same goes for Orlandi, whose form for Argentina A has been very good so it's good for them to join the tour.
"Mariano Galarza has an important physical shape. He started at Universitario La Plata and we know him from his participation in the Buenos Aires regional team. He is very good technically.
"Agustin Figuerola and Nicolas Bruzzone are two young players who have been playing well. They are technically able so we want to take profit from that."
Squad: Eusebio Guinazu (Agen), Horacio Agulla (Brive), Mario Ledesma (ASM Clermont Auvergne), Agustin Figuerola (CASI), Rafael Carballo (Castres Olympique), Martin Durand (Champagnat), Lucas Borges, Federico Martin Aramburu, Nicolas Vergallo (all Dax), Bernardo Stortoni (Glasgow Warriors), Gonzalo Tiesi (Harlequins), Santiago Fernandez (Hindu), Juan Figallo (Jockey Club Salta), Marcos Ayerza (Leicester Tigers), Felipe Contepomi (Leinster), Miguel Avramovic (Montauban), Rimas Alvarez (Perpignan), Alvaro Galindo (Racing Metro), Juan Pablo Orlandi (Rovigo), Juan Martin Fernandez Lobbe (Sale Sharks), Nicolas Bruzzone (SIC), Francisco Leonelli (Saracens), Juan Martin Hernandez, Juan Manuel Leguizamon, Rodrigo Roncero (all Stade Francais), Patricio Albacete, Alberto Vernet Basualdo (both Stade Toulousian), Esteban Lozada (Toulon), Mariano Galarza (Universitario La Plata).
After missing out on England's 2015 RBS 6 Nations campaign through injury, centre Brad Barritt admits he is determined to make up for that disappointment in style with club side Saracens during the season run-in.