Scotland head coach Frank Hadden believes Argentina will provide a familiar and formidable challenge in the first Test in Rosario.
The Pumas defeated Scotland in the quarter-final of the 2007 Rugby World Cup in France en route to a third-placed finish but the match with Scotland marks a new era with Santiago Phelan taking charge for the first time.
Phelan succeeded Marcelo Loffreda, who left Leicester after little more than six months in charge at Welford Road, but selected a well-known line-up with retired duo Agustin Pichot and Gonzalo Longo the only big-name absentees.
And Hadden knows what to expect as Scotland look for a first Test win on Argentinian soil.
"This will be Phelan's first match as boss so I don't expect him to make any drastic change of direction since the last World Cup," Hadden said.
"We have been analysing Argentina in the last six games. When I heard their line-up it was exactly the one that we thought it would be.
"We picked the team two weeks ago and it is just like we said then. There are no surprises. It is a formidable side, full of top-quality players. It will be a huge challenge."
Victory at the Gigante de Arroyito stadium could boost Scotland's ranking, but Hadden is wary of the task which awaits his side. Scotland have not beaten Argentina in six Tests, dating back to 1990.
"Argentina are not just the third best team in the world, they are the third-ranked rugby nation in the world," he added.
"You don't get to third in the ranking just for having a good team.
"We are respectful of the quality the Argentinian players have to offer and we are aware it will be a huge challenge in all parts of the pitch."
Hadden has not been able to call on Craig Smith, Sean and Rory Lamont or Nicky Walker for the tour to South America and has instead chosen to give chances to centre Ben Cairns, lock Matt Mustchin and wing Thom Evans.
Chris Paterson, who is set to equal Scot Murray's record of 87 caps for Scotland, has singled out Federico Todeschini, Bernardo Stortoni and captain Felipe Contepomi as the dangermen.
"I remember playing against Todeschini and we have to be careful," Paterson said. "He is a great player with a very good kick record. He never misses.
"I know Felipe because of playing against each other in the Magners League. I really admire him.
"He is a terrific player, but Argentina have other top-quality players as Bernie Stortoni, who has already proved his courage and skills."
After Ireland's heroic big-game hunt of the Springboks and Scotland's six-try runaround of the Pumas, the challenge of engineering the most spectacular win of the autumn series now falls on Wales, writes Peter Jackson.