Captain Lawrence Dallaglio's men ensured their European fate remains in their own hands with a destructive 40-7 victory over a shadow Llanelli Scarlets side.
Wasps had wrapped up the bonus point by half-time and ended the day top of Pool Five, three points ahead of Munster who were beaten 26-19 by Clermont Auvergne in a tempestuous clash at the Stade Marcel Michelin.
Leicester are the only side to have ever beaten Munster at Thomond Park in the Heineken Cup.
Dallaglio said: "It is a huge challenge but we are aiming to be the second.
"I always thought it would come down to the wire in this group. We are looking forward to a great game and we have to make sure it is us that go through.
"The experience of playing Munster at Thomond Park will be a unique one for all of us."
Dallaglio once again voiced his frustration at the Heineken Cup seeding system, which grouped three of Europe's biggest clubs together and could see two of them bow out before the knockout stages.
Dallaglio said: "It is unfortunate for the competition because all three sides have played some good rugby but that is the reality we all face. There are slightly easier groups where second-placed teams will go through.
"It needs sorting out. You want to see the best sides go through and that is not always going to happen.
"I think we all agree the competition possibly needs reviewing but it is still very exciting."
Wasps have had trouble securing a four-try bonus point this season - but not yesterday.
They had it in the bag by half-time with tries from Fraser Waters, Phil Vickery, David Doherty and Dominic Waldouck.
Wasps continued in a similar vein after the break with Rob Hoadley and Paul Sackey adding to the Scarlets' woe.
Llanelli, three times European Cup semi-finalists, remain the only team in the competition without a point to their name.
"It has been a tough campaign. We have not had anything out of it, which has been disappointing," said boss Phil Davies.
Munster earned what could prove a vital bonus point against Clermont after hitting back from 23-6 down early in the second half.
Munster's cause was helped by the sin-binning of three Clermont players while Ronan O'Gara kicked 14 points, including a conversion to Lifemi Mafi's second-half try.
O'Gara said: "I have to say I didn't realise the bonus point was still in play at the end - it was all a bit crazy.
"People don't realise how tough Clermont are. They're a fantastic side and that was a really tough game.
"We came here looking for the win, and we're disappointed not to have it, but we got the bonus point and that's enough to take into our next game against Wasps."