The westcountry Premiership derby between Gloucester and Bath threw up a new headache for England head coach Andy Robinson after Gloucester prop Phil Vickery sustained a broken forearm.
The injury - picked up in Gloucester's 17-16 win - will keep Vickery out of action for at least six weeks and rule him out of the remainder of the RBS 6 Nations campaign.
Vickery started England's 18-17 defeat to France last weekend and he looked like he would be automatic first choice for Robinson's team, who take on Ireland next weekend at Lansdowne Road - a game England must win having lost twice in the tournament so far.
With Leicester's Julian White also sidelined Robinson does not have any tight head props left in his 30-man squad, forcing him to look at Matt Stevens and Duncan Bell and Northampton's Robbie Morris.
It has been a miserable season for 28-year-old Vickery who has only recently returned to full fitness following a catalogue of injuries.
Gloucester director of rugby Nigel Melville said : "Phil has broken his radius which is the large bone in his forearm. He will go to hospital (on Saturday night) and have a plate put in it.
"I don't really know how it happened but Phil will definitely be out of action for at least six weeks.
"I feel very sorry for him as he has been in great shape. He really needed 80 minutes of rugby (on Saturday) and then this happened to him. Mentally it must be very hard for him."
The bad news did not end there for Robinson - Gloucester's Henry Paul turned his ankle while Bath's Olly Barkley was forced to withdraw from the starting line-up with a calf injury.
Bath head coach John Connolly rates Barkley - who also started against France last weekend - at 50/50 for next weeks Ireland game.
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Italy Under-20s held off a late Samoa blitz to retain their place in the World Rugby U20 Championship on Saturday and head coach Alessandro Troncon believes the experience will have served as a valuable lesson for his young troops.