A clash between the reigning RBS 6 Nations Grand Slam champions and last year's whitewashed wooden spoonists points to only one outcome.
But France's indifferent form in the autumn internationals, allied to their traditional unpredictability, will ensure that Saturday's clash in Paris is no foregone conclusion.
Les Bleus began the autumn series in impressive style with a 27-14 victory over Australia but then defied all logic by slumping to home defeats by Argentina (24-14) and New Zealand (45-6).
France will also go into their opening game without a host of established stars, most notably the entire back row of Imanol Harinordoquy, Olivier Magne and Serge Betsen.
Coach Bernard Laporte has also rung the changes following the record mauling by the All Blacks, with only the front five surviving, and he has adopted a safety-first policy with the selection of 31-year-old fly-half Yann Delaigue, who won the first of his 13 caps when France won at Murrayfield back in 1994.
Scotland, too, are below strength as they attempt to give Australian Matt Williams his first victory as coach.
Already reeling from British Lion Simon Taylor's failure to win his fitness race, the Scots have lost prop Allan Jacobsen and forward Ross Beattie through injury.
The Scots will draw encouragement from Edinburgh's recent shock win over Perpignan in the Heineken Cup, but that match was at a near-deserted Murrayfield.
This time the Scots will have the white-hot atmosphere of a packed Stade de France to contend with and it may not be a pretty sight.
C Paterson (Edinburgh); S Danielli (Borders), A Craig (Glasgow), H Southwell (Edinburgh), S Lamont (Glasgow); D Parks (Glasgow), C Cusiter (Borders); T Smith (Northampton), G Bulloch (Glasgow, captain), G Kerr (Leeds), S Grimes (Newcastle), S Murray (Edinburgh), J White (Sale), A Hogg (Edinburgh), J Petrie (Glasgow).
Replacements: R Russell (London Irish), B Douglas (Borders), N Hines (Edinburgh), J Dunbar (Leeds), M Blair (Edinburgh), G Ross (Leeds), B Hinshelwood (Worcester)
After losing their Under-20s Six Nations crown to England Under-20s in a thrilling final round, France Under-20s lock Tristan Labouteley insists his side will be out for revenge at this year's Junior World Championship.