Ulster duo Matt McCullough and Roger Wilson will make their Ireland debuts against Japan in the first Test in Osaka on Sunday.
Niall O'Donovan's side is a mix of youth and experience and alongside lock McCullough and number eight Wilson will be provincial team-mates David Humphreys, who captains the side, and 21-year-old Tommy Bowe.
Girvan Dempsey, Kevin Maggs, Humphreys, Peter Stringer and Frankie Sheahan provide experience, while Harlequins utility back Gavin Duffy stands in for British & Irish Lions captain Brian O'Driscoll.
Ireland team to play Japan in the first Test in Osaka on Sunday, June 12.
Team: G Dempsey (Leinster); T Bowe (Ulster), G Duffy (Harlequins), K Maggs (Ulster), A Horgan (Munster); D Humphreys (Ulster, capt), P Stringer (Munster); M Horan (Munster), F Sheahan (Munster), S Best (Ulster), L Cullen (Leinster), M McCullough (Ulster), A Quinlan (Munster), J O'Connor (Wasps), R Wilson (Ulster).
Replacements: B Jackman (Connacht), R Corrigan (Leinster), T Hogan (Munster), E Miller (Leinster), K Campbell (Ulster), J Staunton (Wasps), D Quinlan (Leinster).
England flanker James Haskell insists he will be pushing as hard as possible to be back from a toe injury in time to make his case for a spot in Eddie Jones' side looking to defend their RBS 6 Nations title next year.