Jason Robinson has been given the all-clear to resume playing after missing England's final two RBS 6 Nations games through injury.
The 30-year-old is now set to line up for Sale Sharks in Saturday's European Challenge Cup semi-final first-leg tie against Connacht.
Robinson, who took over as England captain from an injured Jonny Wilkinson earlier this season, damaged his thumb during the defeat against Ireland at Lansdowne Road last month and subsequently underwent surgery.
He then missed the Twickenham victories over Italy and Scotland, with Leicester number eight Martin Corry stepping in as skipper.
"The specialist has given me the go-ahead," said full-back Robinson.
"He was satisfied that the injury I sustained playing for England against Ireland had fully healed. I am really looking forward to playing in the game on Saturday."
England's preparations for the Autumn International series were potentially dealt a further blow as Maro Itoje was forced to undergo an x-ray after Saracens' European victory over Scarlets on Saturday night.