Meanwhile Tiger's Skivington comes in for injured Saints star Courtenay Lawes and Abendanon has been brought up from the Saxons squad following Delon Armitage being hit with an eight-week ban.
All four have joined the England squad training in Portugal this week as has Leeds' Hendrie Fourie who is being assessed by medical staff after picking up a calf injury against Bucharest.
There are also seven changes to the Saxons set up preparing for games against Italy A at Worcester and Ireland A in Belfast.
Gloucester duo Olly Morgan and Nick Wood, London Irish hooker James Buckland, Worcester Warriors lock Graham Kitchener, Leicester centre Manu Tuilagi and are named as injury replacements for Matt Mullan (Worcester Warriors), Rob Webber (London Wasps), Dan Ward-Smith (London Wasps), Mathew Tait (Sale Sharks) and Alex Goode (Saracens).
Harlequins lock George Robson replaces the suspended David Attwood (Gloucester Rugby) and Harlequins full back Mike Brown takes over from Abendanon following his promotion to the senior EPS.