And Toulouse stars Yannick Jauzion and Vincent Clerc come in for Damien Traille and Clement Poitrenaud respectively with Maxime Medard, who is a doubt with a thigh injury, moving to full back.
Meanwhile Sebastien Chabal has earned a recall at number eight with Julien Bonnaire missing out and Imanol Harinordoquy moving across to blindside flanker.
"We've decided to change things up a little in the squad and bring in some of the replacements," said Lievremont, whose side were humiliated 34-10 on their last visit to Twickenham in 2009.
"We've gone with the backline which finished the game in Dublin.
"Dimitri has done well twice when he's come on. He's playing well at the moment so it made sense to reward him.
"Morgan is struggling a little but Dimitri is no novice.
"It's good to change things around a bit and give those who deserve it a chance."
15 - Maxime Medard (Toulouse)
14 - Yoann Huget (Bayonne)
13 - Aurelien Rougerie (Clermont Auvergne)
12 - Yannick Jauzion (Toulouse)
11 - Vincent Clerc (Toulouse)
10 - François Trinh-Duc (Montpellier)
9 - Dimitri Yachvili (Biarritz)
1 - Thomas Domingo (Clermont Auvergne)
2 - William Servat (Toulouse)
3 - Nicolas Mas (Perpignan)
4 - Lionel Nallet (Racing Metro)
5 - Julien Pierre (Clermont Auvergne)
6 - Thierry Dusautoir (Toulouse) (captain)
7 - Imanol Harinordoquy (Biarritz)
8 - Sebastien Chabal (Racing Metro)
16 - Guilhem Guirado (Perpignan)
17 - Sylvain Marconnet (Biarritz)
18 - Jerome Thion (Biarritz)
19 - Julien Bonnaire (Clermont Auvergne)
20 - Morgan Parra (Clermont Auvergne)
21 - Damien Traille (Biarritz)
22 - Clement Poitrenaud (Toulouse)