England flanker James Haskell celebrates his try agianst Wales in the 2010 RBS 6 Nations
One of rugby's greatest rivalries will be transported to Friday night for the first time in the opening game of the 2011 RBS 6 Nations.
Since the competition began in 1883, the clash between England and Wales has produced some scintillating fixtures.
After a golden period for English rugby that culminated in the 2003 World Cup win, the balance of power started to shift in Wales' favour.
Indeed since Martin Johnson lifted the William Webb Ellis Trophy, Wales have won four of the last seven Championship matches including a first win at Twickenham in 20 years.
However, one of the more famous encounters of the last two decades was not at the spiritual home of either nation.
Wembley hosted the final match of the 1999 Five Nations and saw Wales achieve one of their most famous wins over their bitterest of rivals delivering a fatal blow to England's Championship hopes in the process.
A last-gasp Scott Gibbs try, converted by Wales stalwart Neil Jenkins, handed the title to Scotland and left the English devastated.
Here, we look at a decade of matches between the countries since the Six Nations Championship formed.
England gained a measure of revenge for their last-gasp defeat at Wembley the year before with a resounding 46-12 win at Twickenham.
The back-row triumvirate of Richard Hill, Lawrence Dallaglio and Neil Back all crossed as did hooker Phil Greening and winger Ben Cohen.
Jonny Wilkinson added 21 points with the boot while Neil Jenkins scored all Wales' points as England went onto win the Championship.
A Will Greenwood hat-trick inspired another emphatic win, 44-15, for Sir Clive Woodward's men in the first Championship match played between the countries at the Millennium Stadium.
Scrum-half Matt Dawson also grabbed two tries with Rob Howley and Scott Quinnell getting consolation tries for the hosts.
For the second year running England went on to capture the Six Nations title but were ultimately denied a Grand Slam in the final round - this time in a delayed 20-14 defeat to Ireland.
England's backs cut loose at Twickenham to seal their heaviest Six Nations defeat of Wales and secure the Triple Crown in the process.
Will Greenwood again crossed along with Tim Stimpson and winger Dan Luger who bagged two tries in the 50-10 hammering.
Star of the show though, was fly-half Jonny Wilkinson who finished with a 30-point 'full house' including a try, a drop goal, four penalties and five conversions.
Fly-half Jonny Wilkinson once again proved Wales' nemesis as he inspired England's 26-9 victory at the Millennium Stadium.
The game was in the balance at halftime with the visitors leading 6-9 before tries from Will Greenwood and Joe Worsley helped England pull away.
Wilkinson notched 16 points with the boot as England finally bagged a Grand Slam in their World Cup winning year.
In the absence of the injured Jonny Wilkinson, newly crowned World Champions England were given a much sterner test by Wales at Twickenham before running out 31-21 winners.
After falling to a shock 19-13 loss to Ireland in the previous match, England blew away some of the cobwebs with Ben Cohen crossing twice and Joe Worsley adding a third.
Olly Barkley, standing in for Wilkinson, notched 16 points to keep the visitors, who got tries through Gareth Thomas and Mark Taylor, at arm's length.
Gavin Henson's late penalty not only gave Wales their first win over England in Cardiff for 12 years but provided the platform for a first Welsh Grand Slam since 1979.
Shane Williams' first half try along with a penalty from Stephen Jones gave the hosts an 8-3 advantage at the break before the boot of Charlie Hodgson edged England in front.
But Henson, who had already left his mark on the game with a thunderous tackle on debutant Mathew Tait, wrote himself into Welsh folklore with his kick from 44m with just four minutes remaining.
England World Cup winner Lawrence Dallaglio made a try-scoring return to international rugby as Andy Robinson's men romped to a 47-13 win against a depleted Wales.
Again the game was evenly poised at halftime, with England leading 15-10 thanks to tries from Mark Cueto and Lewis Moody.
But the Red Rose turned on the style after the break running in another four tries as Dallaglio, having come out of retirement, marked his return in style.
Wales avoided a Six Nations whitewash as James Hook inspired a second consecutive defeat of England at the Millennium Stadium in their 27-18 victory.
England headed into the match with a theoretical chance of bagging their first title in four years, but had not counted on the man-of-the-match performance from Hook.
The fly-half claimed a 22-point full house with prop Chris Horsman claiming the other try.
With new coach Warren Gatland at the helm, Wales finally broke their 20-year hoodoo at Twickenham on the way to completing a second RBS 6 Nations Grand Slam.
A familiar result at Twickenham appeared to be on the cards with England seemingly cruising going into halftime 16-6 ahead.
But an extraordinary second half with tries from Lee Byrne and Mike Phillips along with 16 points from James Hook saw Wales run out 26-19 winners.
Five penalties from fly-half Stephen Jones helped Wales to a hat-trick of Six Nations defeat of England in their 23-15 victory at the Millennium Stadium.
Although England, now under Martin Johnson's charge, outscored the hosts in tries with scores from Paul Sackey and Delon Armitage, they were made to pay for their indiscipline.
Both Mike Tindall and Andy Goode were sin-binned while Jones mercilessly punished their indiscretions with the boot. Winger Leigh Halfpenny grabbed a try for the hosts and also added a long-range penalty.
Alun Wyn Jones' moment of madness helped England get back to winning ways against Wales at Twickenham.
Flanker James Haskell and scrum-half Danny Care both grabbed tries in the ten minutes Jones was in the sin bin for a needless trip on Dylan Hartley.
Although Wales came back into it with tries from James Hook and Adam Jones, an interception led to Haskell getting his second score as England - clad in a special commemorative shirt - ran out 30-17 winners.
Tom Tierney's unbeaten Ireland Women side face an acid test of their title credentials on Sunday when defending Women's Six Nations champions France arrive at Donnybrook Stadium desperate to ensure they remain in the title hunt.