Experienced prop Catrin Edwards is named as skipper while Jamie Kift gains her 80th cap at the weekend and will be joined in the back row by Lisa Newton and Sioned Harris.
Wales will be looking to blood new players with three more uncapped players on the bench in Vici Owens (prop), Sian Williams (lock) and Kerin Lake (full back).
And having worked with Canada at last year's World Cup, de Scossa will be keen to see how his Welsh squad performs against the tournament runners up as he takes charge for the first time.
He said, "They've selected a strong squad and selected a large contingent from the side which played in last year's World Cup final," he said.
"It will be a good test to see where we are. I'm really looking forward to taking England on at Cross Keys where I'm sure we'll be welcomed with open arms," he added.
Wales team to face England:
15 - Aimee Young (Bath Ladies)
14 - Caryl James (Cardiff Quins)
13 - Adi Taviner (Neath Athletic)
12 - Elen Evans (Dolgellau)
11 - Charlie Murray (Neath Athletic)
10 - Elinor Snowsill (Cardiff Quins)
9 - Amy Day (Cross Keys)
1 - Caryl Thomas (Bath Ladies)
2 - Rhian Bowden (Cross Keys)
3 - Catrin Edwards (Cardiff Quins)
4 - Ashley Rowlands (Wasps)
5 - Shona Powell Hughes (Neath Athletic)
6 - Lisa Newton (UWIC)
7 - Sioned Harries (UWIC)
8 - Jamie Kift (Cross Keys)
16 - Lowri Harries (Neath Athletic)
17 - Jenny Davies (Waterloo)
18 - Vici Owens (UWIC)
19 - Sian Williams (Bath Ladies)
20 - Laura Prosser (Cardiff Quins)
21 - Awen Thomas (Cross Keys)
22 - Kerin Lake (Neath Athletic)