Last year's player of the championship, Tommy Bowe, has shrugged off fitness doubts to retake his place on the wing ahead of Fergus McFadden who drops out of the 22.
Sexton meanwhile has to make do with a place on the bench after two less-than-convincing displays against Italy and France.
In both matches O'Gara has replaced Sexton and went on to grab the match-winning drop goal against the Azzurri.
The 33-year-old needs just seven points to reclaim Six Nations points scoring record from Jonny Wilkinson.
Murrayfield has been a happy hunting ground for Ireland in the Six Nations with the last Scotland victory coming ten years ago.
15 - Luke Fitzgerald (Leinster)
14 - Tommy Bowe (Ospreys)
13 - Brian O'Driscoll Leinster)
12 - Gordon D'Arcy (Leinster)
11 - Keith Earls (Munster)
10 - Ronan O'Gara (Munster)
9 - Eoin Reddan (Leinster)
1 - Cian Healy (Leinster)
2 - Rory Best (Ulster)
3 - Mike Ross (Leinster)
4 - Donncha O'Callaghan (Munster)
5 - Paul O'Connell (Munster)
6 - Sean O'Brien (Leinster)
7 - David Wallace (Munster)
8 - Jamie Heaslip (Leinster)
16 - Sean Cronin (Connacht)
17 - Tom Court (Ulster)
18 - Leo Cullen (Leinster)
19 - Denis Leamy (Munster)
20 - Peter Stringer (Munster)
21 - Jonathan Sexton (Leinster)
22 - Paddy Wallace (Ulster)