Centre Mike Tindall takes the captaincy duties from Moody while Louis Deacon replaces Courtney Lawes in the second row as one of three enforced changes made by Martin Johnson from the team that was defeated 21-11 by South Africa.
Johnson turned to Wood having not selected the Northampton flanker in his original 33-man squad for the Six Nations.
But his impressive form for the Saints along with the lineout options his 6ft 5in frame offers have seen Johnson pick Wood at blindside.
That forces Stade Francais star James Haskell into the unfamiliar role of openside flanker with Nick Easter completing the back row.
Other than that Johnson has resisted temptation to tinker with his backline that finished battered and bruised against the Springboks.
That means Toby Flood, preferred to a resurgent Jonny Wilkinson, resumes his half-back partnership with Leicester teammate Ben Youngs.
Wilkinson is included among the replacements as are experienced Wasps duo Simon Shaw and Joe Worsley, and Matt Banahan who will cover the wings and centres.
Eight players including Youngs and Wood will be making their first international starts at the Millennium Stadium in what is bound to be a ferocious atmosphere.
15 - Ben Foden (Northampton Saints)
14 - Chris Ashton (Northampton Saints)
13 - Mike Tindall (Gloucester) Captain
12 - Shontayne Hape Hape (Bath)
11 - Mark Cueto (Sale Sharks)
10 - Toby Flood (Leicester Tigers)
9 - Ben Youngs (Leicester Tigers)
1 - Andrew Sheridan (Sale Sharks)
2 - Dylan Hartley (Northampton Saints)
3 - Dan Cole (Leicester Tigers)
4 - Tom Palmer (Stade Francais)
5 - Louis Deacon (Leicester Tigers)
6 - Tom Wood (Northampton Saints)
7 - James Haskell (Stade Francais)
8 - Nick Easter (Harlequins)
16 - Steve Thompson (Leeds Carnegie)
17 - David Wilson (Bath)
18 - Simon Shaw (Wasps)
19 - Joe Worsley (Wasps)
20 - Danny Care (Harlequins)
21 - Jonny Wilkinson (Toulon)
22 - Matt Banahan (Bath)