Exeter flanker Tom Johnson has been rewarded for his fine season with a call-up while Worcester pair Graham Kitchener and Matt Mullan feature after winning promotion back to the Premiership.
Gloucester centre Henry Trinder and Sale's James Gaskell are other young fliers involved while the experience in the squad is represented by fly-half Charlie Hodgson, Ugo Monye, James Simpson-Daniel and Matt Banahan who featured in the 2011 RBS 6 Nations.
Although it is a non-capped match, England Saxons head coach Stuart Lancaster - who takes charge of the side - maintains it provides the perfect platform for some of England's fringe players to catapult themselves into Martin Johnson's thinking ahead of the 2011 World Cup.
"It's a great opportunity for all the players who are looking to force their way into Martin Johnson's plans for the World Cup and those who will go on to defend the Churchill Cup with the England Saxons next month," said Lancaster.
"We face a very big challenge against the Barbarians, who have a very experienced squad in terms of their average age and number of caps.
"But there's a great deal of quality in the England system at the moment and a lot of these young players will get a chance to benchmark themselves against the best. We've seen that in the way the likes of Ben Youngs, Courtney Lawes, Alex Corbisiero have taken their chances recently.
"A lot of the players have played in big games recently both in Europe and the Aviva Premiership. If we combine them with some of the more experienced players like Paul and Charlie Hodgson, Ugo Monye and James Simpson-Daniel, it should be an exciting combination."
Backs: Mike Brown (Harlequins), James Simpson-Daniel (Gloucester), Ugo Monye (Harlequins), Matt Banahan (Bath), Henry Trinder (Gloucester), Jordan Turner-Hall (Harlequins), Charlie Hodgson (Sale Sharks), Stephen Myler (Northampton), Rory Clegg (Harlequins), Lee Dickson (Northampton), Paul Hodgson (London Irish)
Forwards: Joe Marler (Harlequins), Matt Mullan (Worcester), Kieran Brookes (Newcastle), Paul Doran-Jones (Gloucester), David Paice (London Irish), Joe Gray (Harlequins), Dave Attwood (Gloucester), Graeme Kitchener (Worcester), Calum Clark (Northampton), Carl Fearns (Sale Sharks), Tom Johnson (Exeter), James Gaskell (Sale Sharks), Luke Narraway (Gloucester)