The mouth-watering Twickenham clash between world champions England and RBS 6 Nations title holders Wales promises to provide fireworks aplenty.
But while England look set to opt for a physical approach through their heavyweight pack, Wales know they must fizz and sparkle with a thrilling emphasis on all-out attack that lit up last season's tournament.
England, despite Wales going into battle as Grand Slam champions, are the favourites.
Such status is based on England having reeled off eight successive Twickenham victories against Wales since losing 11-3 in 1988, while Mike Ruddock has lost numerous players through a combination of injuries and suspension.
The absentee list reads like a modern-day who's who of Welsh rugby, with British & Irish Lions Gavin Henson, Ryan Jones, Tom Shanklin and Brent Cockbain among those missing, and England must surely capitalise.
Their pack, apart from prop Matt Stevens replacing Phil Vickery and flanker Joe Worsley starting instead of Pat Sanderson, is the one that gave Australia and New Zealand such torrid examinations during the autumn.
And the forward battle is where England are expected to dominate as they target a winning start ahead of successive RBS 6 Nations trips to Rome and Edinburgh.
England have struggled in the last two RBS 6 Nations campaigns, finishing third and fourth respectively, while only winning five out of 10 games.
But they will be determined to send Wales packing on an afternoon when World Cup hero Lawrence Dallaglio should make his England return off the replacement's bench, some 17 months after retiring from Test rugby.
Conor O'Shea will lead his side to matches against Fiji and Australia
30 March 2017, 2:36pm
After a disappointing RBS 6 Nations campaign for the Azzurri - losing all five of their Championship matches and picking up their 12th Wooden Spoon - they will be licking their wounds ahead of their summer tour Down Under.
The 2017 RBS 6 Nations was watched by record numbers of fans
29 March 2017, 12:25pm
After an enthralling RBS 6 Nations Championship of twists, turns, and no small amount of drama on the last day, figures show the RBS 6 Nations is going from strength to strength, year on year, with no sign of slowing down.