Italy coach Pierre Berbizier has left out Andrea Lo Cicero for the RBS 6 Nations opener against Ireland.
Lo Cicero is a vastly-experienced prop with 49 caps but has been named as one of the replacements at Lansdowne Road on Saturday, with Carlos Nieto set to start in the front row.
Another surprise will see Montpellier's Cristian Stoica play at full-back instead of his usual role at centre.
Italy team to face Ireland at Lansdowne Road:
Cristian Stoica (Montpellier); Pablo Canavosio (Ghial Calvisano), Gonzalo Canale (Clermont-Auvergne), Mirco Bergamasco (Stade Francais), Ludovico Nitoglia (Ghial Calvisano); Ramiro Pez (Perpignan), Paul Griffen; Salvatore Perugini (both Ghial Calvisano), Fabio Ongaro (Benetton Treviso), Carlos Nieto (Arix Viadana), Santiago Dellape (Agen), Marco Bortolami (Narbonne, captain), Josh Sole (Arix Viadana), Mauro Bergamasco, Sergio Parisse (both Stade Francais).
Replacements: Carlo Antonio Festuccia (SKG Gran Parma), Andrea Lo Cicero (Conad L'Aquila), Martin Castrogiovanni (Ghial Calvisano), Carlos Del Fava (Bourgoin), Aaron Persico (Agen), Simon Picone (Benetton Treviso), Rima Wakarua (SKG Gran Parma).
Italy Under-20s held off a late Samoa blitz to retain their place in the World Rugby U20 Championship on Saturday and head coach Alessandro Troncon believes the experience will have served as a valuable lesson for his young troops.