Wales head to Lansdowne Road desperate to keep their RBS 6 Nations Championship defence alive - but after a chaotic fortnight they do so without Grand Slam-winning head coach Mike Ruddock and captain Gareth Thomas.
Ruddock quit on Valentine's night for ''family reasons'', while Thomas was admitted to hospital and ruled out for up to 12 weeks with a damaged artery in his neck.
Amidst all that upheaval, caretaker coach Scott Johnson - heading into his first Test in sole charge - recalled Gavin Henson into the squad. With just one game under his belt since serving a 51-day ban, the 24-year-old is named on the bench.
Lee Byrne replaces Thomas to start at full-back and Dafydd James returns to the wing in place of Shane Williams (dead leg).
Recent events suggest Wales will limp into Dublin a demoralised outfit but Ireland coach Eddie O'Sullivan predicts the opposite.
''There's always a reaction from any team that has gone through a trauma such as a change of coach or a run of losses. It usually galvanises the team and pulls them together,'' he said.
Ireland, meanwhile, have issues of their own to deal with as they look to rebound from a topsy-turvy performance in the 43-31 defeat to France a fortnight ago.
Ireland gifted Les Bleus a 43-3 lead before cutting loose and scoring four quickfire tries in the final 20 minutes.
''If we cut out handing those tries away to any side I think we are going to give them a good game, particularly with the way we know we played in the second half against France,'' said skipper Brian O'Driscoll.
Ireland have replaced Paul O'Connell (shoulder) with British & Irish Lions tourist Donncha O'Callaghan while Andrew Trimble is preferred on the left wing to Tommy Bowe.
Scotland won three matches in this year's Championship
24 March 2017, 3:33pm
Scotland secured three RBS 6 Nations victories for the first time since 2006 as they beat Ireland, Wales and Italy at BT Murrayfield. Here we take a look at what lies ahead for the Scots in the next 12 months.
Peter Malone has been Nigel Carolan's assistant since 2015
24 March 2017, 11:56am
The IRFU have announced Peter Malone as the Ireland Under-20s interim head coach for the World Rugby Under-20 Championship in Georgia this summer after Nigel Carolan announced he would take a position at Guinness PRO12 side Connacht.