Wales coach Scott Johnson has kept faith with the side that was defeated 31-5 by Ireland in Dublin - and has urged the fans to do the same.
Wales, inspired by fly-half Stephen Jones started like a train at Lansdowne Road, but once he limped off with a dead leg they fell to pieces as Ireland ran in three tries and could have had more.
It was a miserable end to a difficult fortnight for Welsh rugby, marked by the departure of Mike Ruddock as head coach and the injury to captain Gareth Thomas.
But Johnson has backed his team to bounce back against the improving Italians this weekend. The only change he has made to the starting XV is to recall Shane Williams after the Ospreys winger recovered from a dead leg.
Injury doubts Stephen Jones and Mark Jones have both been passed fit to play and Johnson has challenged the side to prove their Dublin defeat was just a bad day at the office.
''We have kept the faith with the majority of the side that underperformed in Dublin and told them to go out there on Saturday and put things right,'' said Johnson, who will abandon his position in the coach's box and will be back down on the touchline.
''What we saw against Ireland just wasn't us and my message to the fans is don't give up on us yet, this is our hour of need and we need you now more than ever.''
Italy, despite their obvious improvements this season, are yet to win a game. The Azzurri are still chasing their first away victory since joining the championship in 2000.
This year Italy have matched Ireland, England and France for an hour but they have fallen away each time.
Captain Marco Bortolami has challenged his men to take that next step at the Millennium Stadium.
''We really want to make more than an impact at the Millennium Stadium on Saturday,'' said Gloucester-bound Bortolami.
''All the acclaim for our displays against Ireland and England was good, but now we want more than that - we want to win an RBS 6 Nations 2006 game.''
''This is an occasion to play a positive game and we are going there to find a win.''
Scotland won three matches in this year's Championship
24 March 2017, 3:33pm
Scotland secured three RBS 6 Nations victories for the first time since 2006 as they beat Ireland, Wales and Italy at BT Murrayfield. Here we take a look at what lies ahead for the Scots in the next 12 months.
Peter Malone has been Nigel Carolan's assistant since 2015
24 March 2017, 11:56am
The IRFU have announced Peter Malone as the Ireland Under-20s interim head coach for the World Rugby Under-20 Championship in Georgia this summer after Nigel Carolan announced he would take a position at Guinness PRO12 side Connacht.