Ireland will be confident of clinching a Triple Crown triumph in this season's RBS 6 Nations Championship by beating England at Twickenham on Saturday.
The Irish are chasing a hat-trick of RBS 6 Nations wins against their hosts, and current form suggests they could achieve that feat for a first time since reeling off three victories between 1974 and 1976.
Ireland will encounter an England side virtually unrecognisable from the one beaten 31-6 by France in Paris last weekend.
Andy Robinson has made seven changes, which represents the most radical surgery carried out by an England head coach in a championship match for 20 years.
Matt Stevens has been ruled out with a recurrence of the shoulder injury which saw him miss the 18-12 defeat by Scotland three weeks ago, so Julian White - who was set to be dropped - is handed a reprieve in the front row.
But five other World Cup winners - Josh Lewsey, Mike Tindall, Matt Dawson, Steve Thompson and Danny Grewcock - have been axed from the starting line-up, while injured fly-half Charlie Hodgson is replaced by Andy Goode.
Goode, Wasps centre Stuart Abbott and Bath hooker Lee Mears all make their first RBS 6 Nations starts, with wing Tom Voyce preferred in the number 15 shirt to a more established Lewsey.
Ireland, though, must guard against complacency and a tendency to freeze when the heat is really on.
They cracked badly against Wales in Cardiff last season, as their opponents cruised to the Grand Slam by romping home 32-20, and England are desperate to try and salvage something from a disappointing campaign.
If Ireland can put all the expectancy to one side and concentrate on a powerful 80-minute performance, the likes of skipper Brian O'Driscoll, his fellow centre Gordon D'Arcy and fly-half Ronan O'Gara could enjoy a fruitful day.
England possess plenty of incentive to bounce back from tryless defeats against Scotland and France, but whether they can stop an Irish side that has a degree of momentum remains to be seen.
After losing their Under-20s Six Nations crown to England Under-20s in a thrilling final round, France Under-20s lock Tristan Labouteley insists his side will be out for revenge at this year's Junior World Championship.