They go into the game at the Stadio Peroni full of confidence following last week's emphatic 67-7 win over Wales, although Walshe has opted to make five changes to his side.
Full back Aaron Morris, wing Nathan Earle, fly-half Sam Olver, lock Jonny Hill and No.8 James Chisholm all come into the side, while scrum-half Callum Braley is back on the bench following injury.
Saracens' Maro Itoje will captain the side from the back row with Walshe fully aware of the challenge in front of them.
"We enjoyed the win against Wales but focus is very much on the task in hand and preparing to play a well-drilled Italy side," said Walshe.
"There's no doubt that they have improved over the past couple of seasons and we know that we'll be in for a tough match."
England Under-20s to play Italy Under-20s
15 Aaron Morris (Bedford Blues)
14 Howard Packman (Northampton Saints)
13 Nick Tompkins (Saracens)
12 Harry Sloan (Harlequins)
11 Nathan Earle (Saracens)
10 Sam Olver (Northampton Saints)
9 Henry Taylor (Loughborough University)
1 Danny Hobbs-Awoyemi (Northampton Saints)
2 Harry Thacker (Leicester Tigers)
3 Scott Wilson (Newcastle Falcons)
4 Tom Ellis (Bath Rugby)
5 Jonny Hill (Gloucester Rugby)
6 Maro Itoje (Saracens, captain)
7 Joel Conlon (Exeter Chiefs)
8 James Chisholm (Harlequins)
16 Tom Woolstencroft (Bath Rugby)
17 Alex Lundberg (London Wasps)
18 Paul Hill (Leeds Carnegie)
19 Ross Moriarty (Gloucester Rugby)
20 Hayden Thompson Stringer (Saracens)
21 Callum Braley (Bristol Rugby)
22 Billy Burns (Gloucester Rugby)
23 Henry Purdy (Leicester Tigers)