Defending champions Wales cannot retain their RBS 6 Nations title but they will look to bring the curtain down on their campaign with a flourish when Scotland come to town.
Super Saturday will then climax in Paris where Ireland, after giving Brian O'Driscoll an emotional home send-off in Dublin, will attempt to seal their first title since 2009 against a France side that are also in contention.
The only thing that separates the top three in the RBS 6 Nations table going into the decisive last round of matches is points difference, with Ireland, England and France all being defeated just once in this season's Championship.
England head coach Stuart Lancaster admits he is 'haunted' by Gael Fickou's late match-winning try for France on the opening weekend and well he might be.
Without that the Red Rose would be in the box seat, needing only to win in Rome to claim a Grand Slam but instead they must either overhaul Ireland's superior points difference or, more realistically, hope the Irish are beaten by France.
Luther Burrell may also have some personal glory as his three tries in four games see him tied with Yoann Huget as the 2014 RBS 6 Nations leading try-scorer.
This is the seventh occasion in which Italy have gone into round five having lost their first four games but they avoided the whitewash in 2008 and 2012, beating Scotland in round five on both occasions.
And while English eyes may be on claiming a first title since 2011, Italy may take heart from the fact the Red Rose have been beaten in the final round in two of the last three years.
Even if England do maintain their unbeaten run against Italy, there will be plenty for the home crowd to shout about.
Martin Castrogiovanni, now Italy's most capped player, is ruled out with injury meaning Sergio Parisse, who missed the defeat to Ireland through injury, will earn his 105th cap, drawing level with the prop.
In Cardiff, Wales will be playing for pride but they have not lost successive RBS 6 Nations matches since 2010 and Warren Gatland will be trying to preserve that record on the occasion of the 100th Welsh Test match to be played at the Millennium Stadium.
Scotland were cruelly denied their second win of this year's Championship last Saturday when Jean-Marc Doussain earned France a last-gasp 19-17 victory.
Victory for Wales would make it seven wins in a row against Scotland, equalling their best run of results set between 1908-14 and would be a fitting way to mark Gethin Jenkins becoming the most-capped Welshman of all-time with 105 Wales caps.
The absence of the injured Leigh Halfpenny, the Championship's leading points scorer this season with 51, is a blow to Wales and leaves Ireland fly-half Jonny Sexton (49) and England's Owen Farrell (42) to battle it out for the honour.
By the time the final whistle sounds at the Millennium Stadium the noise will already be deafening at the Stade de France.
For both Ireland and France the equation is simple - they must beat the other and then ensure their points difference is superior to England's, with the Men in Green carrying a significant advantage in that regard.
Ireland boast a plus 81 points difference with England plus 32 and France plus three.
Yet the French boast a formidable home record against Ireland having lost just once in 42 years - a 27-25 loss in 2000 when O'Driscoll inspired Ireland with a hat-trick of tries.
It may be that Ireland will need one last spot of O'Driscoll magic on his final appearance for his country but if last week's man-of-the-match showing is anything to go by it would surprise few if he delivered.
From Rome to Paris it promises to be a thrilling ride as the rugby world tunes in to discover who will win the day on Super Saturday.