Ireland racked up seven tries thanks to Jonathan Sexton (2), Andrew Trimble, Cian Healy, Sean Cronin, Fergus McFadden and Jack McGrath.
As a result Ireland will head to France next week aware that victory will almost certainly see them crowned 2014 RBS 6 Nations champions, such is their superior points difference.
Italy meanwhile, have lost all four of their matches but did show admirable ambition, particularly in the first half, and levelled things up at 7-7 with a well-taken try from Leonardo Sarto.
After the break however, Ireland ran riot and Brunel admits the Azzurri were not up to it defensively.
"The first half with little possession we showed good defence. In second half the possession didn't change but our defence wasn't so competitive as it was in the first half," he said.
"The major weakness was the team's possession. Even against France we were in the game."
Brunel also tipped Ireland to claim a first RBS 6 Nations title since 2009.
He added: "I think Ireland can win the tournament because they have great continuity and they have shown they can sustain that over the whole 80 minutes and showed it also against the All Blacks last year."