O'Driscoll, 35, will make his 140th appearance for Ireland in Dublin, surpassing Australian George Gregan's previous record.
But with Italy currently without a win in this year's RBS 6 Nations, Bortolami is fully focussed on the job at hand.
The Azzurri will be looking to claim their first win in Dublin since 1997 and the 33-year-old lock believes it is possible.
"I don't think they will change the way they play because of Brian's 140th game," said Bortolami, Italy's skipper in Sergio Parisse's absence.
"After the game I'm sure that will get some attention. But we will try to destroy this party for him.
"We don't want to disrespect him, but that's the way sport is. I'm sure it's a motivation for Ireland, but to be honest we haven't talked about that.
"We have to do our job, turn up and execute our gameplan, that's what we can control."