O'Driscoll, 35, will surpass Australian scrum-half George Gregan's record of 139 Test appearances when he lines up at the Aviva Stadium this weekend, in what will also be his final international appearance in Dublin.
Despite a 13-10 loss to England at Twickenham last time out, Ireland still sit atop the RBS 6 Nations table although England, Wales and France are all level with them on four points with just two games remaining.
And with his side in contention to win the RBS 6 Nations in his final season, O'Driscoll is adamant that he is approaching the Italy match just like any other, despite the personally historic nature of the occasion.
"It doesn't feel any different; it's just hard when you just want to get on with it," said O'Driscoll.
"Yeah, I'm excited a lot about a home game for sure in that it will be one to remember, but at the same time and more importantly it's about putting us in position to win the Championship.
"That's really been the main focus. I won't think about the final games until it's done and dusted and I'll reflect on it afterwards.
"I'm not really that emotional a person, so I won't allow the build-up to it to affect me; what will happen will affect me organically."