Scotland have lost to England, Ireland and Italy in their opening three games and host unbeaten France at Hawthornden, Lasswade on Sunday.
Head coach Jules Maxton has made five changes to the side beaten 45-5 by Italy last time out, including Griffith who plays alongside Sarah Law in a new half-back combination in Scotland's 2014 Women's Six Nations campaign.
As a result, Louise Dalgliesh and Lisa Martin will be on the bench but Griffith is confident the changes can breed a better result.
Griffith said: "Although we've not managed to record a win this year, thereare a lot of positives we can take from our games.
"We just need to stay focussed and get our mentality right. We're sometimes guilty of putting our heads down instead of concentrating on the game.
"We know France will be tough, but there's a sense of genuine belief and excitement in the camp that we can get a win this weekend, especially following a strong second-half performance against Italy."