Following an emphatic defeat to Wales last time out, Saint-Andre has made seven changes to his side with Sebastien Vahaamahina coming in at flanker, Maxime Machenaud starting at scrum-half and Maxime Mermoz making his first appearance of the Championship at inside centre.
Les Bleus remain in the hunt for the RBS 6 Nations despite defeat to Wales, having beaten England and Italy in their opening two matches but face a Scotland side resurgent following victory over Italy in Rome.
History is with France however, they have won 13 of their 14 Championship meetings with Scotland and Saint-Andre has called on his side to get their campaign back on track.
"We are expecting a bit reaction from the players so that our supporters can be proud of their team at Murrayfield," he said.
"We can still win the tournament, many people seem to have forgotten that but we will be very focused on this match.
"We will need courage, some spark, an enormous desire from everyone individually and collectively.
"We are going to try and be intelligent, to play as a team.
"In Cardiff that did not happen, not for us the staff in terms of how we prepared for the match but also the players at the start of the match."