In total, Saint-Andre has made seven changes with an all new back-row that features Sebastien Vahaamahina in the unfamiliar position of flanker, Alexandre Lapandry and Damien Chouly.
At scrum-half Maxime Machenaud gets his first start of the competition, replacing Jean-Marc Doussain while Maxime Medard comes back onto the left wing for Hugo Bonneval.
Wesley Fofana is out through injury, ensuring there will be a first 2014 RBS 6 Nations appearance for Maxime Mermoz at inside centre while, with Dimiti Szarzewski also sidelined, Brice Mach starts at hooker.
"Players owe themselves a chance of revenge," Saint-Andre said.
"Let's not lie to ourselves, we were just not there against Wales. We were beaten on the essence of our sport: combat."
Vahaamahina made his debut for France off the bench against Australia in 2012 at flanker but all of his subsequent ten caps have come in the second row.
But injury to Yannick Nyanga as well as Saint-Andre's decision to drop Louis Picamoles for his reaction to receiving a yellow card against Wales has left France short of back row options.
On the bench, hooker Guilhem Guirado could make his first appearance of the Championship while prop Rabah Slimani returns following suspension.
FRANCE SIDE TO FACE SCOTLAND
15. Brice Dulin (Castres)
14. Yoann Huget (Toulouse)
13. Mathieu Bastareaud (Toulon)
12. Maxime Mermoz (Toulon)
11. Maxime Medard (Toulouse)
10. Jules Plisson (Stade Francais)
9. Maxime Machenaud (Racing Metro)
1. Thomas Domingo (Clermont)
2. Brice Mach (Castres)
3. Nicolas Mas (Montpellier)
4. Pascal Pape (Stade Francais)
5. Yoann Maestri (Toulouse)
6. Sebastien Vahaamahina (Perpignan)
7. Alexandre Lapandry (Clermont)
8. Damien Chouly (Clermont)
16. Guilhem Guirado (Perpignan)
17. Vincent Debaty (Clermont)
18. Rabah Slimani (Stade Francais)
19. Alexandre Flanquart (Stade Francais)
20. Antoine Claassen (Castres)
21. Jean-Marc Doussain (Toulouse)
22. Remi Tales (Castres)
23. Gael Fickou (Toulouse)