Webb has been handed his second start for Wales, keeping his place after impressing against France last time out, in a side that welcomes back Jonathan Davies and Alun Wyn Jones.
Victory over Les Bleus last time out saw Wales stay in the hunt for an unprecedented third RBS 6 Nations title and under Warren Gatland Wales have an impressive record at Twickenham, having won the Kiwi's first match in charge in 2008 as well as their last visit, a 19-12 triumph.
It's an earlier memory that Webb recalls however, citing Wales' 1999 victory over England at Wembley - courtesy of Scott Gibbs' famous try - as his inspiration.
"My earliest memory of Wales-England games was when Scott Gibbs went over to score that winning try at Wembley," he said.
"He did something special because we hadn't beaten them for a while. Everyone speaks about that score and whatever else happens in these matches, because Wales and England are rivals.
"You think about those things - players who have scored winning tries - and you hope one day it will be you.
"When I was growing up, everyone would talk about the big battles between Wales and England. Those are the matches you want to be involved in, the heated battles.
"I came across them with Wales U16s and U18s. They were a very big side then, but we had a strong team as well with the likes of Warby (Sam Warburton) and Jon Davies. They were always good, even matches - and I think we won both games."