Hartley listed opposite number Richard Hibbard, No.8 Taulupe Faletau and centre Jamie Roberts - all three prominent ball-carriers - as Wales' danger men.
Victory is set to decide who remains in the hunt for the RBS 6 Nations title on the final weekend and Hartley admits stopping that trio will be crucial to England's success.
"We obviously look at talismen in other teams, I prefer to call them targets. That's not a joke," he said.
"You respect them because they provide a lot of momentum, but if you make them a target, it changes that.
"In every team it's the No.8 who is the big go-forward man - David Denton, Louis Picamoles, Jamie Heaslip and now Faletau.
"If you see a big man being stopped, psychologically that's huge. I look at my opposite number Hibbard - he's very powerful for them.
"They like to put Roberts up the middle of the field then Hibbard round the corner on a big strong carry.
"It's nothing complicated but they do it very well. They're very powerful blokes.
"I don't think you focus on them - it's not mindless targeting - but if you get an opportunity you always take it."