The British & Irish Lion star is back playing for club side Scarlets following a pectoral injury last November, but has yet to pull on a Red Dragons jersey since then.
Davies' made a lasting impact on Tour with the Lions in Australia last summer - making his mark in all three Tests - and at just 25, has already appeared 37 times for Wales.
And with next weekend's crunch clash against England at Twickenham fast approaching, Howley is keeping a close eye on the centre's performances for the Scarlets.
"It is good to have a quality player back in the selection mix," said Howley. "He is a huge talent who matured particularly well with the Lions and was fantastic last year.
"He has become a senior player within our leadership group, and the combination of him and Jamie [Roberts] has flourished. Having him available would be a huge boost for Wales.
"We just hope he can prove his fitness. We just have to see how he comes through the game on Saturday.
"He played against London Irish [on February 1] and there is always going to be a feeling that you are off the pace a bit.
"He has trained extremely well since the Irish game and this is a second match for him. Hopefully, fingers crossed, he will come through very well."