The 22-year-old has started all three games for les Bleus during the RBS 6 Nations, including the disappointing 27-6 defeat to Wales last time out.
But with a week before France's next championship clash, away to Scotland at Murrayfield, he was back in action for Stade, coming off the bench for the final ten minutes against Montpellier.
It was to no avail however, as Montpellier picked up a 19-10 win to move second in the Top 14, just ahead of Stade.
The fly-half was not the only member of the French squad in action, skipper Pascal Papé came off the bench while tightheads Rabah Slimani and Nicolas Mas both started the game.
And Plisson admits that it's not easy switching from international to club mode on the rest weekends.
He said: "From a personal point of view it's difficult to go from France to playing for my club. And during the championship it's also difficult to leave your friends.
"Of course we have some regrets. We played very well in the first half. We wanted to keep that going in the second, of even pick up the pace. Instead we conceded 12 points very quickly.
"From then on it became difficult. We needed to pick up at least a bonus point from this game. There are lots of games left and we've got home games against a lot of other play-off teams. This defeat slows us down a little. We've come away with no points, like against Brive and Clermont. I hope that won't be costly."