Shane Horgan will start on the right wing in a back-line which features his fellow Ireland internationals Girvan Dempsey and Gordon D'Arcy when Leinster face Edinburgh in the Magners League on Friday night.
With Brian O'Driscoll rested, D'Arcy will be partnered in midfield by Fergus McFadden.
In the Leinster pack, Sean O'Brien is introduced to form a back row partnership with Cameron Jowitt and Stephen Keogh, two more new inclusions.
Ireland duo Trevor Hogan and captain Leo Cullen will link up in the second row for Leinster's second away trip in five days.
UCD and Ireland Under-20 back Ian McKinley, untried at this level, is a notable inclusion on the province's replacements bench.
O'Brien said: "There's a lot of confidence in the squad right now. The Harlequins win has given us a lift and we know that the real hard work starts now.
"There are a few places up for grabs so the message for those of us who weren't involved last week is that we will have to work hard to get into the team.
"I have enjoyed getting a run of games and being involved in big games, like the Wasps victory at home, gave me a taste of the level that's required. It's up to us this weekend to make a mark and take our chances."
Robin McBryde was assistant coach with Wales during the Championship
27 March 2017, 11:19am
Wales secured wins against Italy and Ireland in the 2017 RBS 6 Nations but were beaten in Paris and Edinburgh as well as suffering defeat to England in Cardiff. Here we take a look at what lies ahead for Wales in the next 12 months.