Ospreys will be without injured Wales stars Gavin Henson and Lee Byrne for the daunting trip to reigning champions Munster in the quarter-finals of the Heineken Cup tomorrow.
Ireland wing Tommy Bowe has been switched to full-back in Byrne's absence, while Sonny Parker and Andrew Bishop form the centre pairing as the Welsh region look to go one step further than last season when they were dumped out of Europe by Saracens.
Ospreys head coach Sean Holley said: "We have a group of players with an appetite to go and prove they can produce the goods on such a big stage.
"We are just concentrating on ourselves, and I hope Ireland's Grand Slam will put more pressure on them (Munster)."
England's preparations for the Autumn International series were potentially dealt a further blow as Maro Itoje was forced to undergo an x-ray after Saracens' European victory over Scarlets on Saturday night.