The Lions hopes of Scotland flanker Alasdair Strokosch look to be all but over after he was deemed unlikely to play again this season.
Strokosch has been left out of Gloucester's squad for the EDF Energy Cup final against Cardiff Blues after being substituted in the Premiership match against Northampton.
As revealed on www.rbs6nations.com last week, the injury which forced him from the field against was not a straightforward one and has led to the former Edinburgh having neurological tests.
As a result of the injury, which has seen Strokosch suffer 'stingers' in his arms and shoulders, Gloucester do not expect their powerful forward to play again this season.
The lay-off comes at the worst possible time for the big-hitting flanker, with Lions coach Ian McGeechan weighing up his options for the tour to South Africa this weekend ahead of the squad announcement on Tuesday.
It is also a bad time for the Cherry and Whites, who are bracing themselves for three fixtures in the space of eight days which will define their inconsistent season.
England's preparations for the Autumn International series were potentially dealt a further blow as Maro Itoje was forced to undergo an x-ray after Saracens' European victory over Scarlets on Saturday night.