The Anglo-Welsh cup holders are also chasing Heineken Cup and Magners League success.
And they will head to Coventry's Ricoh Arena this weekend boosted by the return of several Wales internationals from RBS Six Nations duty, including Gavin Henson, Shane Williams, James Hook, Adam Jones, Ian Gough and Ryan Jones.
Holley said: "This game marks the start of a huge month for us as we look to keep alive our involvement in three competitions.
"It is going to be a difficult period in terms of rugby, but it's an exciting time.
"Everything we've done as a group over the last eight months or so has been geared towards being in contention on three fronts come the end of March, and here we are."