Scotland assistant coach Andy Robinson has opted to give several of his international stars a break this weekend with the start of the RBS 6 Nations just a fortnight away.
Scotland captain Mike Blair leads the list of those left out by Edinburgh for the final group game in this year's European Cup.
Greig Laidlaw takes his place at scrum-half for the game against Leinster - so Scotland forward Allister Hogg leads the side.
Former Test skipper Chris Paterson replaces fellow Scotland squad member Hugo Southwell, who has a shoulder problem, at full-back.
Meanwhile, Edinburgh swap one Scotland centre for another as Nick De Luca returns after a head knock to form a centre partnership with John Houston as Ben Cairns drops out to give him a rest before the RBS 6 Nations.
Stand-off David Blair will make only his second start of the season against the Celtic League champions instead of Phil Godman, who is nursing a slight hamstring strain.
Italy Under-20s held off a late Samoa blitz to retain their place in the World Rugby U20 Championship on Saturday and head coach Alessandro Troncon believes the experience will have served as a valuable lesson for his young troops.