Quins, looking to complete a Premiership double over Wasps this season, give a start to Chris Brooker in the front row instead of hooker Tani Fuga, with Gonzalo Tiesi resuming his centre partnership alongside Jordan Turner-Hall.
And Quins' England wing Ugo Monye has hailed the impact of New Zealand fly-half Nick Evans, whose December displays were pivotal to memorable home and away Heineken Cup victories over Stade Francais, plus a thrilling Premiership draw against Leicester at Twickenham.
Monye, who opposes England colleague Sackey tomorrow, said: "Nick has had a huge impact on creating the environment we have at the club.
"He is one of the best fly-halves in the world and the experience he brings - he has had a year playing in New Zealand under the experimental law variations - is immense.
"He got injured after our first game of the season, but what he offered from a technical and analysis point of view was brilliant.
"Just look at the last three weeks, and what he has produced for Harlequins is massive.
"He just keeps proving what a class player he is."