Only Alex Corbisiero, Mike Brown, Richard Wigglesworth and Ben Morgan have more than ten caps in a side that catches the eye for its array of exciting ball players.
On the bench there are no less than six uncapped players and Lancaster believes the match will prove a useful tool as England gear up for their trip to South America.
"Taking on a very experienced Barbarians team is the first challenge they face this summer with matches in Uruguay and Argentina to follow and this sequence of games is a key part of our development as a team," said Lancaster.
"Webber finished the season strongly with Bath and I know his leadership qualities well. I am sure he'll show the way backed up by the other senior players in the team."