In a positional change, captain Ellis Jenkins switches to the blindside with flanker Sion Bennett sitting out the game through injury.
Dragons duo Hallam Amos and Jack Dixon take up places on the bench while Blues outside half Rhys Patchell is also unavailable for the Scotland trip through injury.
Wilson said: "Ashley Evans has been playing well on the wing, but it's a case of preparing for the Junior World Championship and tweaking the side to give players opportunities as we have done throughout this tournament.
"It's not a case of regional players walking straight into the side but, at the same time, it's great to create competition within the squad.
"This Scotland side is the best Scottish age grade side I've seen in a good few years. They've beaten Italy and Ireland and ran England close so we are going to have to be at the top of our game to come away with a result.
"The set-piece is key, as it has been throughout our Six Nations campaign, and hopefully the weather will be an improvement on the conditions in Italy and allow us to play some attacking rugby."