He is hopeful however, that his first appearance in Lancaster's starting XV will come against Italy on Sunday where he could be joined by 20-year-old brother Billy.
Billy Vunipola has been in superb form for Wasps this season and has been knocking on the door of England's matchday squads having been invited to join the senior squad's training camp at Pennyhill Park.
"To get a first start would be something special and especially at Twickenham, it would be a great occasion for me and my family," said Mako.
"It's always hard to be on the bench, but obviously we know as players that it's still a massive thing and we've got a job to come on and make an impact.
"Hopefully I've made an impact every time I've come on, but I know I've still got a lot to learn and I'm happy to learn off the players we have here."
On playing with Billy for England he added: "That's the dream for us, to be out there together for my family. Hopefully one day that will happen."