Les Bleus have lost just once in their last 13 matches with the Men in Green - in 2009 when Ireland won the Grand Slam - and Saint-Andre can take heart from the improved performance last time out against England.
At Twickenham, Morgan Parra played a large part in French improvements and he and fly-half Frederic Michalak will start together for the first time in this year's Championship.
And while Saint-Andre acknowledges that part of his side's role is to entertain, he would take a victory on Saturday, regardless of how it came about.
"The French team's role is to win and win well but in our situation, we'd take a 3-0 victory," said Saint-Andre.
"You've got to make your own luck. We didn't face up to the situation in the first three matches.
"We've got to score when we're playing well, concede fewer points when we're not (and) be better defensively.
"Against England, when we scored, we weren't aggressive enough in the first line of defence. We missed a lot of first tackles.
"We've worked on that to be tighter against Ireland. We've got to learn to win matches again."