And all that is left for Wales to do in order to seal the title outright is to avoid defeat against England who themselves would retain their RBS 6 Nations crown if they triumph by any score.
Wilson has made four changes from the side that triumphed 42-17 over the Scots last week with Dragons centre Jack Dixon making his first start of the campaign.
Ashley Evans returns to the left wing in place of the injured Aaron Warren and prop Nicky Smith and hooker Elliot Dee appear in the front row alongside Nicky Thomas.
But with a sell-out crowd predicted at Colwyn Bay this Friday night, Wilson believes such support could make all the difference when the two teams face off.
"We are of course pleased with the way this tournament has panned out for us, playing England for the chance of winning the Six Nations and Grand Slam is a fantastic opportunity for these players ahead of the Junior World Championship in June," said Wilson.
"We have matured as a squad during the tournament, but we will have to sharpen up in a number of areas if we are to beat England on Friday.
"Our discipline especially must improve - we can't give away penalties and yellow cards to a side like England and expect to come away with a result.
"It's brilliant to know we will be playing in front of a sell-out crowd. The support at Eirias has been superb for every one of our games, the backing gives the players a real boost and could really make a difference on Friday."