There are numerous new faces in the 22-man Argentina squad to face Ireland in the first Test on May 26.
Saracens back Tomas de Vedia, Biarritz prop Gaston de Robertis and CASI lock James Stuart are among the uncapped men on duty for the match at Santa Fe.
There are nine players from English and Scottish clubs, including Leeds lock Pablo Bouza.
The countries, who clash in a World Cup group game in September, meet in the second Test in Buenos Aires on 2 June.
Argentina squad - forwards: M Ayerza, P Bouza, G de Robertis, M Durand, J M Fernandez Lobbe, G Fessia, P Gambarini, S Gonzalez Bonorino, J Leguizamon, E Lozada, J Stuart, A Basualdo.
Backs: M Avramovic, F Contepomi, T de Vedia, J Miranda, F Leonelli, L Fleming, H Senillosa, F Serra, B Stortoni, N Vergallo.
The RBS 6 Nations Championship 2015 was not poised to go down as one of the more "vintage" Championships, though there was great anticipation as the action headed into its final day. What transpired was something that nobody could foresee: "The Greatest Day in Rugby's Greatest Championship."