There are numerous new faces in the 22-man Argentina squad to face Ireland in the first Test on May 26.
Saracens back Tomas de Vedia, Biarritz prop Gaston de Robertis and CASI lock James Stuart are among the uncapped men on duty for the match at Santa Fe.
There are nine players from English and Scottish clubs, including Leeds lock Pablo Bouza.
The countries, who clash in a World Cup group game in September, meet in the second Test in Buenos Aires on 2 June.
Argentina squad - forwards: M Ayerza, P Bouza, G de Robertis, M Durand, J M Fernandez Lobbe, G Fessia, P Gambarini, S Gonzalez Bonorino, J Leguizamon, E Lozada, J Stuart, A Basualdo.
Backs: M Avramovic, F Contepomi, T de Vedia, J Miranda, F Leonelli, L Fleming, H Senillosa, F Serra, B Stortoni, N Vergallo.
As head coach Stuart Lancaster polishes the axe he will soon wield over his World Cup training squad, Exeter Chiefs coach Rob Baxter has backed Jack Nowell, Henry Slade and Luke Cowan-Dickie to be given a stay of execution.
Italy Under-20s held off a late Samoa blitz to retain their place in the World Rugby U20 Championship on Saturday and head coach Alessandro Troncon believes the experience will have served as a valuable lesson for his young troops.